Mast Cell Tryptase (TPSB2) Rabbit mAb说明书

发表时间：2023-10-17

Mast Cell Tryptase (TPSB2) Rabbit mAb

Application:WB,IHC-P

PROPERTIES

Synonyms

TPS1; TPS2; TPSB1; TPSB2; Tryptase-2

Source

Rabbit

Purification

Affinity purification

Observed MW

31kDa

Calculated MW

31kDa

Cross Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 30-275 of human Mast Cell Tryptase

Isotype

IgG

Recommended Dilutions

WB 1:500 - 1:2000

IHC-P 1:50 - 1:200

Formulation

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Storage instructions

Store at -20℃. Avoid freeze / thaw cycles.

Background

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the

5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent

two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders

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Synonyms	TPS1; TPS2; TPSB1; TPSB2; Tryptase-2
Source	Rabbit
Purification	Affinity purification
Observed MW	31kDa
Calculated MW	31kDa
Cross Reactivity	Human, Mouse, Rat
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 30-275 of human Mast Cell Tryptase
Isotype	IgG
Recommended Dilutions	WB 1:500 - 1:2000 IHC-P 1:50 - 1:200
Formulation	PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Storage instructions	Store at -20℃. Avoid freeze / thaw cycles.
Background	Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders